Docking of CDK1 with antibiotic drugs revealed novel therapeutic value in breast ductal cancer in situ

作者：Ding, Zhong-Hai; Qi, Jia; Shang, An-Quan; Zhang, Yu-Jie; Wei, Jun; Hu, Li-Qing^*; Wang, Wei-Wei^*; Yang, Man^*

来源：Oncotarget, 2017, 8(37): 61998-62010.

DOI：10.18632/oncotarget.18779

• ductal cancer in situ
• GEO
• molecular signature
• microarray
• protein docking

The aim of our research is to identify potential genes associated with Ductal carcinoma in situ (DCIS) through microarrays. The microarray dataset GS54665 were downloaded from the GEO(Gene Expression Omnibus) database. Dysregulated genes were screened and their associations with DCIS was analyzed by comprehensive bioinformatics tools. A total of 649 differential expression genes were identified between normal and DCIS samples, including 224 up-regulated genes and 425 down-regulated genes. Biological process annotation and pathway enrichment analysis identified several DCIS-related signaling pathways. Finally, PPI network was constructed with String website in order to get the hub codes involved in Ductal carcinoma in situ. We thus concluded that Five genes: CDK1, CCNB2, MAD2L1, PPARG, ACACB were finally identified to participate in the regulation and serve as potential diagnosis signatures in in Ductal carcinoma in situ. Finally, complmentarity between CDK1 and three drugs, Aminophenazone, Pomalidomide and the Rosoxacin, implies novel pharmacological value of those drugs in breast cancer.

• 出版日期2017-9-5
• 单位南京医科大学; 宁夏医科大学; 南京大学; 同济大学; 南京中医药大学