Artificial apolipoprotein corona enables nanoparticle brain targeting

作者：Dal Magro Roberta; Albertini Barbara; Beretta Silvia; Rigolio Roberta; Donzelli Elisabetta; Chiorazzi Alessia; Ricci Maurizio; Blasi Paolo^*; Sancini Giulio

来源：Nanomedicine: Nanotechnology, Biology and Medicine , 2018, 14(2): 429-438.

DOI：10.1016/j.nano.2017.11.008

• Lipid nanoparticles
• Protein corona
• Apolipoprotein E4
• Brain targeting
• Blood brain barrier

Many potential therapeutic compounds for brain diseases fail to reach their molecular targets due to the impermeability of the blood-brain barrier, limiting their clinical development. Nanotechnology-based approaches might improve compounds pharmacokinetics by enhancing binding to the cerebrovascular endothelium and translocation into the brain. Adsorption of apolipoprotein E4 onto polysorbate 80-stabilized nanoparticles to produce a protein corona allows the specific targeting of cerebrovascular endothelium. This strategy increased nanoparticle translocation into brain parenchyma, and improved brain nanoparticle accumulation 3-fold compared to undecorated particles (119.8 vs 40.5 picomoles). Apolipoprotein decorated nanoparticles have high clinical translational potential and may improve the development of nanotechnology-based medicine for a variety of neurological diseases.

• 出版日期2018-2
• 单位Perugia