Association between maternal and umbilical cord serum dipeptidyl peptidase IV in pregnant women with and without gestational diabetes mellitus

作者：Liu, Bin; Deng, Songqing; Xu, Yun; Yang, Juan; Geng, Huizhen; Wang, Zilian^*

来源：Journal of Obstetrics and Gynaecology Research, 2016, 42(5): 505-510.

DOI：10.1111/jog.12931

• dipeptidyl peptidase IV
• gestational diabetes mellitus
• insulin secretion
• neonatal anthropometry

AimThe aim of the present study was to investigate maternal and umbilical cord serum dipeptidyl peptidase IV (DPP4) concentrations in women with and without gestational diabetes mellitus (GDM), and to evaluate a potential correlation between neonatal anthropometry and cord serum DPP4 concentration. @@@ MethodsTwenty-eight GDM and 25 normal glucose tolerance (NGT) pregnant women were recruited into the present study. Maternal and umbilical cord serum DPP4 concentrations were measured by enzyme immunoassay. Maternal and neonatal clinical data, glucose, insulin, triglyceride, cholesterol, high-density lipoprotein, and low-density lipoprotein were recorded and measured for analysis. @@@ ResultsA statistically significant positive correlation was observed between maternal and umbilical cord serum DPP4 concentrations (Spearman's correlation coefficient = 0.804, P < 0.001; partial correlation coefficient r' = 0.884, P < 0.001). No significant difference was seen when comparing DPP4 concentrations for the GDM and NGT groups' maternal serum (P = 0.498), or their umbilical cord serum (P = 0.449). No statistically significant correlations were observed between umbilical cord serum DPP4 concentration and the presence of neonatal anthropometry or metabolic factors. @@@ ConclusionUmbilical cord serum DPP4 concentration is associated with maternal DPP4 concentration, but is not related to neonatal anthropometry or metabolic factors. No significant difference was observed between the GDM and NGT groups in maternal or cord serum DPP4 concentrations.

• 出版日期2016-5
• 单位中山大学