Asymmetric organocatalytic Michael addition of ketones to vinyl sulfone

作者:Zhu Qiang; Cheng Lili; Lu Yixin*
来源:Chemical communications, 2008, (47): 6315-6317.
DOI:10.1039/b816307c

摘要

Highly enantioselective organocatalytic Michael addition of ketones to vinyl sulfone catalyzed by a cinchona alkaloid-derived primary amine is reported for the first time; the described synthetic methodology was applied to the synthesis of sodium cyclamate.

  • 出版日期2008