Mitochondrial dysfunction and oxidative stress in aging and cancer

作者：Kudryavtseva Anna V; Krasnov George S; Dmitriev Alexey A; Alekseev Boris Y; Kardymon Olga L; Sadritdinova Asiya F; Fedorova Maria S; Pokrovsky Anatoly V; Melnikova Nataliya V; Kaprin Andrey D; Moskalev Alexey A; Snezhkina Anastasiya V

来源：Oncotarget, 2016, 7(29): 44879-44905.

DOI：10.18632/oncotarget.9821

• oxidative stress
• mitochondrial dysfunction
• ROS
• aging
• cancer
• Gerotarget

Aging and cancer are the most important issues to research. The population in the world is growing older, and the incidence of cancer increases with age. There is no doubt about the linkage between aging and cancer. However, the molecular mechanisms underlying this association are still unknown. Several lines of evidence suggest that the oxidative stress as a cause and/or consequence of the mitochondrial dysfunction is one of the main drivers of these processes. Increasing ROS levels and products of the oxidative stress, which occur in aging and age-related disorders, were also found in cancer. This review focuses on the similarities between ageing-associated and cancer-associated oxidative stress and mitochondrial dysfunction as their common phenotype.

• 出版日期2016-7-19