Antioxidant and antigenotoxic effects of rosemary (Rosmarinus officinalis L.) extracts in Salmonella typhimurium TA98 and HepG2 cells

作者：Zegura Bojana^*; Dobnik David; Niderl Masa Hojnik; Filipic Metka

来源：Environmental Toxicology and Pharmacology, 2011, 32(2): 296-305.

DOI：10.1016/j.etap.2011.06.002

• Antioxidants
• Antigenotoxicity
• Bacterial reverse mutation assay
• Comet assay
• HepG2 cells
• Rosmarinus officinalis L

In the present study the chemopreventive effects of water soluble AquaROX (R) 15 and oil soluble VivOX (R) 40 rosemary extracts against 4-nitroquinoline-N-oxide (NQNO) and 2-amino-3-methyl-3H-imidazo[4,5-F]quinoline (IQ) induced mutagenicity in the reverse mutation assays with Salmonella typhimurium TA98 and against t-butyl hydroperoxide (t-BOOH), benzo(a)pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced DNA damage in HepG2 cells were studied, applying the comet assay. The results showed comparable protective effect of AquaROX and VivOX against oxidative DNA damage, whereas protection against indirect active genotoxic carcinogens was more efficient by VivOX.

• 出版日期2011-9