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摘要
Changes in ambient temperature produce complex effects on sleep-wakefulness. In order to find out the mechanisms involved in temperature-sensitive changes in sleep in rats, their thermal preference, body temperature and sleep were studied before and after the destruction of both peripheral and central warm receptors, by systemic administration of 375 mg/kg capsaicin. Though the pre-treated rats preferred to stay mostly at the ambient temperature of 27 degrees C, post-treated rats strayed freely into chambers having ambient temperature of 30 degrees C and 33 degrees C. Sleep and body temperature of these rats were studied for six hours each, when they were kept at an ambient temperature of 18-36 degrees C. Total sleep time, especially REM sleep, was maximum at 30 degrees C in pre-treated rats, but this REM sleep peak at 30 degrees C disappeared after capsaicin administration. Body temperature increased sharply in post-treated rats, at ambient temperatures above 30 degrees C. Apart from the ability to defend body temperature at high ambient temperature, avoidance of warm ambient temperature and increase in REM sleep are the behavioral measures which are lost in post-treated rats. Results of this study suggest that the ambient temperature-related increase in REM sleep at 30 degrees C could be part of the thermoregulatory measures.
- 出版日期2012-8
- 单位河北医科大学
