Neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritis

作者：Suzuki Michiko; Wiers Kristina M; Klein Gitelman Marisa S; Haines Kathleen A; Olson Judyann; Onel Karen B; O'Neil Kathleen; Passo Murray H; Singer Nora G; Tucker Lori; Ying Jun; Devarajan Prasad; Brunner Hermine I^*

来源：Pediatric Nephrology, 2008, 23(3): 403-412.

DOI：10.1007/s00467-007-0685-x

• NGAL
• biomarker
• systemic lupus erythematosus (SLE)
• pediatric SLE (pSLE)
• lupus nephritis
• Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)

We hypothesized that neutrophil gelatinase-associated lipocalin (NGAL) is an early predictive biomarker of disease activity in lupus nephritis. NGAL in serial plasma (PNGAL) and urine (UNGAL) samples was measured by enzyme-linked immunosorbent assay (ELISA) in 85 participants with pediatric systemic lupus erythematosus (pSLE), healthy children (n=50), and children with juvenile idiopathic arthritis (JIA) (n=30). Disease activity was measured by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Plasma and urinary NGAL were significantly increased in subjects with pSLE compared with those with JIA or with healthy controls (all p < 0.03), and unrelated to subjects' age, weight, or height. Plasma and urinary NGAL were stable in pSLE subjects with unchanged disease activity. The pSLE subjects with worsening global or renal disease activity had a mean +/- standard error (SE) increase of UNGAL (in ng/ml) of 11.5 +/- 6.4 or 36.6 +/- 12.1 (p < 0.01), corresponding to a 156% or 380% increase, respectively. PNGAL increased with worsening disease but to a much lesser degree than UNGAL [global disease activity (mean +/- SE): 7.3 +/- 6.2 or 21%; renal disease activity: 20.2 +/- 6.0 or 51%; both p=not significant]. In conclusion, NGAL in urine but not in plasma represents a novel biomarker for renal disease activity in pSLE.

• 出版日期2008-3
• 单位西北大学