Height and risk of melanoma: a systematic review and meta-analysis

作者：Yu, Dao-Jiang; Li, Xiu-Jie; Morice, Anne; Wu, Li-Jun; Sun, Wei; Zhao, Tian-Lan^*

来源：International Journal of Clinical and Experimental Medicine, 2018, 11(5): 4426-4435.

• Height
• melanoma
• association
• risk factor

This systematic review and meta-analysis of prospective cohort studies aimed to comprehensively estimate the relationship between height and melanoma risk. Prospective cohort studies were identified through literature search in Pubmed and EMBASE. The summary relative risk (RR) with 95% confidence interval (95% CI) was calculated using random-effects meta-analysis. Twelve studies with a total of 4,723,739 participants and 20,049 melanoma cases were included. When compared with individuals with the lowest category of height, individuals with the top category of height had increased risk of melanoma (Random-effects RR = 1.46, 95% CI 1.24 to 1.73; P < 0.001). Per 10-cm increment in the height was positively correlated with increased melanoma risk (Random-effects RR = 1.27, 95% CI 1.19 to 1.35; P < 0.001). Subgroup analysis by gender showed that RRs of melanoma risk associated with per 10-cm increment in height in women and men were 1.27 (95% CI 1.18 to 1.36; P < 0.001) and 1.52 (95% CI 1.01 to 2.29; P = 0.04), respectively. There is strong evidence for the relationship between height and melanoma risk.

• 出版日期2018
• 单位苏州大学