Antinociceptive and wound healing activities of Croton adamantinus Mull. Arg. essential oil

作者：Ximenes Rafael Matos^*; Nogueira Lenise de Morais; Rodrigues Cassunde Nathalia Maria; Bezerra Jorge Roberta Jeane; dos Santos Simone Maria; Machado Magalhaes Lucimere Paulino; Silva Monalisa Ribeiro; de Barros Viana Glauce Socorro; Araujo Renata Mendonca; da Fonseca Ribeiro de Sena Kesia Xisto; Cavalcanti de Albuquerque Julianna Ferreira; Martins Rene Duarte

来源：Journal of Natural Medicines, 2013, 67(4): 758-764.

DOI：10.1007/s11418-012-0740-1

• Croton adamantinus
• Wound healing
• Antinociceptive
• Antimicrobial
• Ethnopharmacology
• Caatinga
• Essential oil

Leaves of Croton adamantinus have been used to treat inflammation and skin wounds in the semi-arid area of the Northeast of Brazil. In order to evaluate if the essential oil (EO) was responsible for the claimed activities; antinociceptive, wound healing and antimicrobial tests were carried out. Twenty constituents were identified in C. adamantinus EO by GC-MS, H-1-NMR and C-13-NMR, the major compounds being methyl-eugenol (14.81 %) and 1,8-cineol (13.74 %). Antinociceptive activity was evaluated by the formalin test and the abdominal contortion assay in mice. The EO (50 and 100 mg/kg) decreased the licking time of both phases of the formalin test when compared to the vehicle, but not to morphine (7.5 mg/kg). In the abdominal contortion assay, the EO (50 and 100 mg/kg) reduced the number of contortions compared to the vehicle and to indometacin (10 mg/kg). The wound healing activity was verified also using two experimental models: excisional wound and dead space. Topical treatment with the EO (1 %) increased the wound contraction from the third day of treatment (compared with nitrofurazone 0.2 %), while systemic treatment (50 mg/kg/day) increased granulation tissue formation and reduced the water content. C. adamantinus EO also showed antimicrobial activity against Staphylococcus aureus in disk diffusion method. These results corroborate the ethnobotanical use of this specie by Brazilian population.

• 出版日期2013-10