Antiretroviral Drug-Related Liver Mortality Among HIV-Positive Persons in the Absence of Hepatitis B or C Virus Coinfection: The Data Collection on Adverse Events of Anti-HIV Drugs Study

作者：Kovari Helen^*; Sabin Caroline A; Ledergerber Bruno; Ryom Lene; Worm Signe W; Smith Colette; Phillips Andrew; Reiss Peter; Fontas Eric; Petoumenos Kathy; De Wit StePhane; Morlat Philippe; Lundgren Jens D; Weber Rainer

来源：Clinical Infectious Diseases, 2013, 56(6): 870-879.

DOI：10.1093/cid/cis919

• liver-related mortality
• drug toxicity
• antiretroviral therapy
• HIV infection
• cohort study

Background. Liver diseases are the leading causes of death in human immunodeficiency virus (HIV)-positive persons since the widespread use of combination antiretroviral treatment (cART). Most of these deaths are due to hepatitis C (HCV) or B (HBV) virus coinfections. Little is known about other causes. Prolonged exposure to some antiretroviral drugs might increase hepatic mortality. %26lt;br%26gt;Methods. All patients in the Data Collection on Adverse Events of Anti-HIV Drugs study without HCV or HBV coinfection were prospectively followed from date of entry until death or last follow-up. In patients with liver-related death, clinical charts were reviewed using a structured questionnaire. %26lt;br%26gt;Results. We followed 22 910 participants without hepatitis virus coinfection for 114 478 person-years. There were 12 liver-related deaths (incidence, 0.10/1000 person-years); 7 due to severe alcohol use and 5 due to established ART-related toxicity. The rate of ART-related deaths in treatment-experienced persons was 0.04/1000 person-years (95% confidence interval, .01, .10). %26lt;br%26gt;Conclusions. We found a low incidence of liver-related deaths in HIV-infected persons without HCV or HBV coinfection. Liver-related mortality because of ART-related toxicity was rare.

• 出版日期2013-3-15