Anomalous relation between axial length and retinal thickness in amblyopic children

作者：Kok Pauline H B^*; de Kinkelder Roy; Braaksma Besselink Yvette C; Kalkman Jeroen; Prick Lie**eth J J M; Sminia Marije L; Mourits Maarten Ph; Verbraak Frank D

来源：Journal of AAPOS, 2013, 17(6): 598-602.

DOI：10.1016/j.jaapos.2013.09.005

PURPOSE TO investigate the relationship between retinal thickness and axial length in amblyopic eyes compared to healthy eyes. %26lt;br%26gt;METHODS In this observational, transversal study, 36 amblyopic children and 30 healthy controls underwent full ophthalmological and orthoptic examinations, volume scanning of the macula with spectral domain optical coherence tomography (3D OCT-1000; Topcon Corporation, Tokyo, Japan), and measuring of axial length using the IOLMaster (Carl Zeiss Meditec AG, Jena, Germany). The average pericentral retinal thickness was calculated. %26lt;br%26gt;RESULTS A strong correlation was observed between the axial lengths of both eyes in the control group (R = 0.98, P %26lt; 0.01) and between the axial lengths of the amblyopic and fellow eye in the amblyopic group (R = 0.77, P %26lt; 0.01); the amblyopic and their fellow eyes were significantly shorter than the nonamblyopic control eyes. The pericentral retinal thickness of both eyes of an individual is highly correlated in nonamblyopic controls (R = 0.92, P %26lt; 0.01) and in amblyopic children (R = 0.82, P %26lt; 0.01). There is no significant difference in mean pericentral retinal thickness between healthy, amblyopic, and fellow eyes. In healthy eyes a moderate inverse correlation exists between axial length and pericentral retinal thickness (R = -0.41, P = 0.02); this relationship was not found in the amblyopic eyes or the normal fellow eye. %26lt;br%26gt;CONCLUSIONS In this patient cohort, there was an anomalous relation between the axial length and the pericentral retinal thickness in both amblyopic and their fellow eyes.

• 出版日期2013-12