Acetyl Eburicoic Acid from Laetiporus sulphureus var. miniatus Suppresses Inflammation in Murine Macrophage RAW 264.7 Cells

作者：Saba Evelyn; Son Youngmin; Jeon Bo Ra; Kim Seong Eun; Lee In Kyoung; Yun Bong Sik^*; Rhee Man Hee

来源：Mycobiology, 2015, 43(2): 131-136.

DOI：10.5941/MYCO.2015.43.2.131

• Acetyl eburicoic acid
• Anti-inflammation
• Laetiporus sulphureus var. miniatus
• Nitric oxide
• Proinflammatory cytokine

The basidiomycete Laetiporus sulphureus var. miniatus belongs to the Aphyllophorales, Polyporaceae, and grows on the needleleaf tree. The fruiting bodies of Laetiporus species are known to produce N-methylated tyramine derivatives, polysaccharides, and various lanostane triterpenoids. As part of our ongoing effort to discover biologically active compounds from wood-rotting fungi, an anti-inflammatory triterpene, LSM-H7, has been isolated from the fruiting body of L. sulphureus var. miniatus and identified as acetyl eburicoic acid. LSM-H7 dose-dependently inhibited the NO production in RAW 264.7 cells without any cytotoxicity at the tested concentrations. Furthermore it suppressed the production of proinflammatory cytokines, mainly inducible nitric oxide synthase, cyclooxygenase-2, interleukin (IL)-1 beta, IL-6 and tumor necrosis factor a, when compared with glyceraldehyde 3-phosphate dehydrogenase. These data suggest that LSM-H7 is a crucial component for the anti-inflammatory activity of L. sulphureus var. miniatus.

• 出版日期2015-6