Are FoxP3+cells involved in hyporesponsiveness to interferon/ribavirin therapy in chronic hepatitis C?

作者：Westin J^*; Hellstrand K; Dhillon A P; Lagging M

来源：Journal of Viral Hepatitis, 2011, 18(2): 149-151.

DOI：10.1111/j.1365-2893.2010.01277.x

• antiviral treatment
• Foxp3
• hepatitis C virus
• histopathology
• immunohistochemistry
• regulatory T cells
• tregs

We aimed to clarify the role of liver-infiltrating FoxP3+T cells for the response to therapy in chronic hepatitis C. Liver biopsies from 52 patients were collected prior to the start of interferon/ribavirin treatment, and the kinetics of viral decay during treatment were compared in patients with high and low infiltration of FoxP3+ cells. These groups did not differ with respect to the effectiveness of early viral clearance or the frequency of sustained viral response. Our data imply that FoxP3+ cell-mediated immunosuppression is not a major mechanism of hyporesponsiveness to interferon-based therapy in chronic hepatitis C.

• 出版日期2011-2