Association of the CMIP rs2925979 polymorphism and several environmental factors with serum lipid levels in the Chinese Jing and Han populations

作者：Shi, Guang-Yuan; Yin, Rui-Xing^*; Guo, Tao; Sun, Jia-Qi; Chen, Xia; Pan, Ling; Huang, Jian-Hua; Li, Wei-Jun; Gao, Hui; Zhang, Qing-Hui

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(12): 12632-12650.

• Lipids
• sex-specific association
• c-Maf inducing protein (CMIP)
• single nucleotide polymorphism
• environmental factors

The c-Maf inducing protein gene (CMIP) rs2925979 single nucleotide polymorphism (SNP) has been associated with serum high-density lipoprotein cholesterol (HDL-C) levels in the individuals of European ancestry in a previous genome-wide association study, but the reproducibility of this association has not been detected in the other populations. The aim of the present study was to explore the association of the CMIP rs2925979 SNP and several environmental factors with serum lipid levels in the Chinese Jing and Han populations. Genotyping of the CMIP rs2925979 SNP in 552 unrelated subjects of Jing ethnic group and 632 participants of Han nationality was performed by polymerase chain reaction and restriction fragment length polymorphism, and then confirmed by direct sequencing. Serum total cholesterol (TC) and triglyceride levels were higher in Jing than in Han (P < 0.01 for each). The genotypic and allelic frequencies of the SNP were not different between the Jing and Han populations, but the genotypic frequencies of the SNP in Han but not in Jing were different between males and females (18.9%, 52.8% and 28.3% vs. 18.5%, 43.4% and 38.0%; respectively, P = 0.028). Serum HDL-C levels in the Jing population were different among the genotypes (P = 0.048), the G allele carriers had higher HDL-C levels than the G allele noncarriers. Serum TC levels in the Han population were different among the genotypes (P = 0.007), the G allele carriers had lower TC levels than the G allele non-carriers, subgroup analyses showed that this finding was restricted to Han females but not Han males. Multivariate linear regression analyses revealed that serum HDL-C and apolipoprotein (Apo) B levels in the combined population of Jing and Han, and serum HDL-C levels and the ApoA1/ApoB ratio in Jing were correlated with genotypes (P < 0.05 for all). Serum lipid phenotypes were also correlated with several environmental factors in the Jing and Han populations, or in males and females of the both ethnic groups (P < 0.05-0.001). These findings suggest that there may be an ethnic-and/or sex-specific association of the CMIP rs2925979 SNP and serum lipid levels in our study populations.

• 出版日期2016
• 单位广西医科大学