Differences in genetic variants in lopinavir disposition among HIV-infected Bantu Africans

作者：Mpeta Bafokeng; Kampira Elizabeth; Castel Sandra; Mpye Keleabetswe L; Soko Nyarai D; Wiesner Lubbe; Smith Peter; Skelton Michelle; Lacerda Miguel; Dandara Collet

来源：Pharmacogenomics, 2016, 17(7): 679-690.

DOI：10.2217/pgs.16.14

• ABCC2
• Africa
• antiretroviral therapy
• CYP3A4/5
• lopinavir
• pharmacogenetics
• SLCO1B1

Introduction: Variability in lopinavir (LPV) plasma concentration among patients could be due to genetic polymorphisms. This study set to evaluate significance of variants in CYP3A4/5, SLCO1B1 and ABCC2 on LPV plasma concentration among African HIV-positive patients. Materials & methods: Eighty-six HIV-positive participants on ritonavir (LPV/r) were genetically characterized and LPV plasma concentration determined. Results & discussion: LPV plasma concentrations differed >188-fold (range 0.0206-38.6 mu g/ml). Both CYP3A4*22 and SLCO1B1 rs4149056G (c.521C) were not observed in this cohort. CYP3A4*1B, CYP3A5*3, CYP3A5*6 and ABCC2 c.1249G>A which have been associated with LPV plasma concentration, showed no significant association. Conclusion: These findings highlight the need to include African groups in genomics research to identify variants of pharmacogenomics significance

• 出版日期2016-5