Acylation of Grignard reagents mediated by N-methylpyrrolidone: A remarkable selectivity for the synthesis of ketones

作者:Gowda Maravanhalli Sidde; Pande Sushanth Sudhir; Ramakrishna Ramesha Andagar*; Prabhu Kandikere Ramaiah
来源:Organic and Biomolecular Chemistry, 2011, 9(15): 5365-5368.
DOI:10.1039/c1ob05780d

摘要

An efficient user-friendly method of acylation of Grignard reagents to selectively synthesize ketones is presented, which is assisted by simple amides such as NMP, or DMF. The present chemoselective method tolerates a variety of functional groups such as ketone, ester, nitrile and other functional groups.

  • 出版日期2011