Analysis of diltiazem and its related substances by HPLC and HPLC/MS

作者：Quaglia MG^*; Donati E; F****i S; Bossu E; Montinaro A; Buiarelli F

来源：Journal of Pharmaceutical and Biomedical Analysis, 2005, 37(4): 695-701.

DOI：10.1016/j.jpba.2004.11.050

• diltiazem
• impurities
• classical reversed stationary phases
• monolithic support
• HPLC
• HPLC/MS

Diltiazem (DTZ) is an optically active calcium channel blocker having a benzodiazepine structure. The drug used in therapy is (+)-cis-diltiazem with configuration (2S, 3S). To describe the analytical profile of DTZ different stationary phases (RP-18, RP-8, monolithic support) were tested. The best separation of DTZ from A, 13, E and F was obtained using as stationary phase a RP-8 or a monolithic RP-18. The characterization of impurities was carried out using two analytical systems, HPLC and HPLC/MS.

• 出版日期2005-4-1