科研之友
微信
新浪微博
Facebook
分享链接
摘要
OBJECTIVE: To evaluate the anticancer, antioxidant and antimicrobial activities along with total phenolic and flavonoids contents extracted from Lespedeza bicolor indigenous to Khyber Pukhtoonkhwa, Pakistan. METHODS: Anticancer activity against human lung carcinoma (LU-1) and human prostate carcinoma (LnCap), antimicrobial against Aspergillus fumigates, Aspergillus niger, Fusarium solani, Mucor sp Klebsiella pneumonia and Enterococcus and antioxidant activity on 1,1-Dipheny1-2-picryl-hydrazyl (DPPH) and Hydrogen peroxide radicals scavenging activity were assessed in methanol extract of Lespedeza bicolor. RESULTS: Lespedeza bicolor aerial parts and root extract showed IC50 value of 12.5 and 50 mu g/mL against LU-1 whereas, <= 12.5 and 12 mu g/mL were calculated against LnCap cell line. Minimum inhibition concentration (MIC) value of 20-35 mu g/mL has been observed against Aspergillus fumigates, Aspergillus niger, Fusarium solani and Mucor sp in comparision with 1-2.5 mu g/mL of Terbinafine used as a standard fungicide. MIC value of 20 and 35 mu g/mL of Lespedeza bicolor aerial parts and root extract against bacterial pathogen Klebsiella pneumonia and 20-50 mu g/mL against Enterococcus has been measured. DPPH radical scavenging activity of Lespedeza bicolor with IC50 values of <= 50 mu g/mL and <= 200 mu g/mL was observed whereas, hydrogen peroxide scavenging activity with IC50 values of <= 25 mu g/mL for aerial parts and <= 50 mu g/mL for the root extract of Lespedeza bicolor has been shown. CONCLUSION: These data suggested that the methanolic extract of Lespedeza bicolor could be potential candidates for natural antioxidants and anticancer.
- 出版日期2017-8
