Gene-Environment Interaction in Alzheimer%26apos;s Disease

作者：Singh Neeraj Kumar; Chhillar Neelam^*; Banerjee B D; Bala Kiran; Mukherjee Ajit Kumar; Mustafa M D; Mitrabasu

来源：American Journal of Alzheimer's Disease and Other Dementias, 2012, 27(7): 496-503.

DOI：10.1177/1533317512456067

• Alzheimer%26apos
• s disease
• gene-environment interaction
• organochlorine pesticides
• APOE polymorphism
• beta-HCH
• dieldrin

Objectives: The aim was to examine the gene environment (GxE) interaction with reference to APO E genotypes, serum lipids and organochlorine pesticides (OCPs) as one of the factors in the etiology of Alzheimer%26apos;s disease (AD). Methods: A case control study was used to examine, APOE HhaI polymorphism by polymerase chain reaction (PCR)/PCRrestriction fragment length polymorphism method, serum lipids by autoanalyser and OCPs by gas chromatography (GC). Results: APOE epsilon 4 allele frequency was significantly high (p=0.000, OR=5.73, CI=2.68-12.50) in AD as compared to controls. The serum cholesterol, beta- hexachlorocyclohexane and dieldrin are risk factors for AD independent of the APOE epsilon 4 risk allele, recording an odds ratio of 1.16, 11.38 and 10.45 respectively. Conclusion: GxE interactions exist with APOE e4 allele status that need to be considered for the study design and analysis of such data in future studies of AD.

• 出版日期2012-11