Alzheimer's disease: the silver tsunami of the 21st century

作者：Sarkar Ankita; Irwin Madison; Singh Aditi; Riccetti Matthew; Singh Amit

来源：Neural Regeneration Research, 2016, 11(5): 693-697.

DOI：10.4103/1673-5374.182680

• Alzheimer's disease
• neurodegeneration
• amyloid plaques
• amyloid hypothesis
• animal models
• drosophila melanogaster
• drosophila eye

Alzheimer's disease (AD), a fatal progressive neurodegenerative disorder, has no cure to date. One of the causes of AD is the accumulation of amyloid-beta 42 (A beta 42) plaques, which result in the onset of neurodegeneration. It is not known how these plaques trigger the onset of neurodegeneration. There are several animal models developed to (i) study etiology of disease, (ii) look for genetic modifiers, and (iii) identify chemical inhibitors that can block neurodegeneration and help to find cure for this disease. An insect model of Drosophila melanogaster has also provided new insights into the disease. Here we will discuss the utility of the Drosophila eye model to study Alzheimer's disease.

• 出版日期2016-5