Nanocrystalline hydroxyapatite doped with aluminium: A potential carrier for biomedical applications

作者：Kolekar Tanaji V^*; Thorat Nanasaheb D; Yadav Hemraj M; Magalad Veeresh T^*; Shinde Mahesh A; Bandgar Sneha S; Kim Jin H; Agawane Ganesh L

来源：Ceramics International, 2016, 42(4): 5304-5311.

DOI：10.1016/j.ceramint.2015.12.060

• Sol-gel processes
• Nanocomposites
• Apatite
• Biomedical applications

Biocompatible materials based on hydroxyapatite are potentially attractive for a wide range of medical applications. The effect of aluminium substitution on the biocompatibility of hydroxyapatite (HA) under the physiochemical conditions has been investigated. Various samples of aluminium doped hydroxyapatite (Al-HA) with different concentration (0, 0.5, 1.0, 1.5, 2.0, 2.5 mol%) were successfully synthesised by solution combustion method and characterized by X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Scanning Electron Microscopy (SEM), and thermal analysis technique. XRD and TEM results reveal uniform and crystalline nature of Al-HA nanoparticles. The biocompatibility of the Al-HA nanoparticles was studied using L929 cell lines by MTT assays up to 24 h. These Al-HA nanoparticles are biocompatible on cell lines L929 and do not have toxic effects for further possible in vivo applications. The results of these studies confirmed the biocompatibility of Al-HA and demonstrated the suitability for biomedical applications. The present work reveals the importance of structural, morphological, biocompatible properties of Al-HA nanoparticles and predicts the suitability for biomedical applications.

• 出版日期2016-3