Antiepileptic action of exogenous dehydroepiandrosterone in iron-induced epilepsy in rat brain

作者：Mishra Monika; Singh Rameshwar; Sharma Deepak^*

来源：Epilepsy and Behavior, 2010, 19(3): 264-271.

DOI：10.1016/j.yebeh.2010.06.048

• Iron-induced epilepsy
• Dehydroepiandrosterone
• Electrical seizures
• Seizure
• Na(+), K(+)-ATPase activity
• Lipid peroxidation
• Protein oxidation
• Morris water maze test
• Open-field test

In the study described here, the antiepileptic effect of dehydroepiandrosterone (DHEA) treatment on iron-induced focal epileptiform activity in the rat brain was investigated. DHEA is a neuroactive corticosteroid hormone synthesized both in the adrenal cortex and in the brain. Its antioxidant properties are well known. As oxidative stress seems to play a major role in epileptogenesis in the iron-induced model of posttraumatic epilepsy, it was of interest to examine whether DHEA would exert antiepileptic activity. DHEA at a dose of 30 mg/kg/day administered intraperitoneally for 7, 14, and 21 days to iron-induced epileptic rats prevented epileptiform electrophysiological activity. Morris water maze and open-field tests on iron-induced epileptic rats revealed that DHEA also prevented behavioral alterations related to epileptiform activity. Thus, DHEA attenuated the cognitive defects produced by epileptic activity. Moreover, alterations in epileptogenesis-related biochemical parameters-lipid peroxidation, protein oxidation and Na(+), K(+)-ATPase (sodium pump) activity-were also countered by DHEA.

• 出版日期2010-11