A nanocomplex of Cu(II) with theophylline drug; synthesis, characterization, and anticancer activity against K562 cell line

作者：Sahlabadi Maryam; Daryanavard Marzieh; Hadadzadeh Hassan; Amirghofran Zahra

来源：Journal of Molecular Structure, 2018, 1155: 450-456.

DOI：10.1016/j.molstruc.2017.11.029

• Nanocomplex
• Nanoparticles
• FE-SEM
• Anticancer activity
• K562 cell line
• Cytotoxicity

A new mononuclear of copper (II), [Cu(theophylline)(2)(H2O)(3)]center dot 2H(2)O, has been synthesized by reaction of theophylline (1,3-dimethy1-7H-purine-2,6-dione) with copper (II) nitrate in water. Further, its nano complex has been prepared through the three different methods including sonication, grinding, and a combination thereof, sonication-grinding. The prepared nanocomplex was characterized using different techniques including FT-IR, UV-Vis, X-ray diffraction (XRD) analysis, and field-emission scanning electron microscopy (FE-SEM). Moreover, the anticancer activity of the precursor complex, nanocomplex, free theophylline ligand, and the starting copper salt (Cu(NO3)(2)center dot 3H(2)O) was investigated against the K562 cell line. The results show that the nanocomplex is an effective nano metal based anticancer agent with IC50 = 11.7 mu M.

• 出版日期2018-3-5