A tour through the transcriptional landscape of platelets

作者:Schubert Sebastian; Weyrich Andrew S; Rowley Jesse W*
来源:Blood, 2014, 124(4): 493-502.
DOI:10.1182/blood-2014-04-512756

摘要

The RNA code found within a platelet and alterations of that code continue to shed light onto the mechanistic underpinnings of platelet function and dysfunction. It is now known that features of messenger RNA (mRNA) in platelets mirror those of nucleated cells. This review serves as a tour guide for readers interested in developing a greater understanding of platelet mRNA. The tour provides an in-depth and interactive examination of platelet mRNA, especially in the context of next-generation RNA sequencing. At the end of the expedition, the reader will have a better grasp of the topography of platelet mRNA and how it impacts platelet function in health and disease.

  • 出版日期2014-7-24