One-pot three-component solvent-free synthesis of 1-[(1,3-thiazol-2-ylamino)methyl]-2-naphthols

作者：Li Zheng^*; Mao Xuerong

来源：Heterocyclic Communications, 2011, 17(5-6): 219-222.

DOI：10.1515/HC.2011.045

• aldehyde
• heteroarylamine
• Mannich reaction
• multicomponent synthesis
• 2-naphthol

A series of 1-[(1,3-thiazol-2-ylamino) methyl]-2-naphthols were synthesized via one-pot three-component Mannich reaction of 2-aminothiazoles, aldehydes and 2-naphthol under solvent-free conditions. This protocol has advantages of no use of volatile organic solvents and hazardous catalysts. Work-up procedure is simple and yields are high.

• 出版日期2011-12
• 单位西北师范大学