Apical Periodontium Response to Enamel Matrix Derivative as an Intracanal Medication in Rat Immature Teeth with Pulp Necrosis: Radiographic and Histologic Findings

作者：Scarparo Roberta Kochenborger; Dondoni Lenara; Boettcher Daiana Elisabeth; Grecca Fabiana Soares; Figueiredo Jose A P; Batista Eraldo L Jr^*

来源：Journal of Endodontics, 2012, 38(4): 449-453.

DOI：10.1016/j.joen.2011.12.041

• Apical
• enamel matrix proteins
• inflammation
• nonvital teeth
• odontogenesis
• periodontium

Introduction: The aim of this study was to evaluate the enamel matrix derivative (EMD) biomaterial in nonvital immature teeth. Methods: To arrest root development, pulpectomies were performed in the lower first molars of 36 4-week-old rats; the cavities were left exposed to the oral environment for 3 weeks. Then, chemical disinfection was performed, and triple antibiotic paste (TAP) or EMD was applied in the root canals. A control group did not receive any treatment. Radiographic and histological data were evaluated after 3 and 6 weeks. Results: At 3 weeks, TAP promoted a milder inflammatory response and increased root lengths compared with the control group. At 6 weeks, root development and reduced periapical lesions could be observed in both test groups, mainly because of the deposition of a cementum-like tissue. EMD promoted narrower canals compared with TAP (P < .05). Conclusions: EMD deserves attention as a potential tool in the treatment of nonvital immature teeth. The ingrowth of cementum-like tissues into canal spaces favored dental wall thickness and may contribute to tooth resistance and support. (J Endod 2012;38:449-453)

• 出版日期2012-4