科研之友
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摘要
The purpose of the study was to determine if longitudinal measurements of enamel autofluorescence ( quantitative light-induced fluorescence, QLF) could detect differences in remineralization of early enamel caries on buccal surfaces of anterior teeth following supervised daily brushing with either sodium fluoride ( NaF; 1,450 ppm F), sodium monofluorophosphate ( MFP; 1,450 ppm F) dentifrices or a herbal, nonfluoride placebo dentifrice. The study was a pragmatic cluster-randomized controlled trial with schools as the unit of randomization. Twenty-one schools in Chengdu, China, comprised the clusters; 296 children with at least 1 visible white-spot lesion were examined using QLF at baseline and after 3 and 6 months. Each of the 21 clusters was randomly assigned 1 of the 3 dentifrices, and the children brushed under supervision once per day for 2 min. The primary outcome measure was Delta Q ( product of fluorescence loss and area) at a 5% threshold after 6 months of product use. A multi-level model was fitted to the data at the site level, taking into account the hierarchical structure with baseline Delta Q, age and sex as covariates. After 3 months there was a significant difference between the MFP group and placebo ( p = 0.02) and after 6 months between the NaF group ( p = 0.002), MFP group ( p < 0.001) and the placebo. QLF methodology could detect, within 3- and 6-month periods of supervised brushing, a difference in remineralization between fluoride-containing and non-fluoride-containing dentifrices. Typically lesions in all 3 treatment groups demonstrated improvement. Groups receiving fluoride experienced a more rapid and more substantial remineralization than those in the placebo group.
- 出版日期2007
- 单位四川大学
