Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors

作者：Sluis Cremer Nicolas^*; Tachedjian Gilda

来源：Virus Research, 2008, 134(1-2): 147-156.

DOI：10.1016/j.virusres.2008.01.002

• HIV
• reverse transcriptase
• non-nucleoside
• Gag-Pol
• viral entry

The non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are a therapeutic class of compounds that are routinely used, in combination with other antiretroviral drugs, to treat HIV-1 infection. NNRTIs primarily block HIV-1 replication by preventing RT from completing reverse transcription of the viral single-stranded RNA genome into DNA. However, some NNRTIs, such as efavirenz, have been shown to inhibit the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing, while others, such as the pyrimidinediones, have been shown to inhibit both HIV-1 RT-mediated reverse transcription and HIV-1/HIV-2 viral entry. Accordingly, in this review we describe the multiple mechanisms by which NNRTIs inhibit HIV-1 reverse transcription (and in some cases HIV-2 reverse transcription) and other key steps involved in HIV-1/HIV-2 replication.

• 出版日期2008-6
• 单位河北医科大学