Acetaminophen use during pregnancy: effects on risk for congenital abnormalities

作者：Rebordosa Cristina^*; Kogevinas Manolis; Horvath Puho Erzsebet; Norgard Bente; Morales Maria; Czeizel Andrew E; Vilstrup Hendrik; Sorensen Henrik T; Olsen Jorn

来源：American Journal of Obstetrics and Gynecology, 2008, 198(2): 178.e1.

DOI：10.1016/j.ajog.2007.08.040

• abnormalities
• acetaminophen
• analgesics
• pregnancy outcomes
• teratogens

OBJECTIVE: We evaluated if acetaminophen, one of the most frequently used drugs among pregnant women is associated with an increased prevalence of congenital abnormalities.
STUDY DESIGN: We selected 88,142 pregnant women and their live-born singletons from the Danish National Birth Cohort who had information on acetaminophen use during the first trimester of pregnancy. We used the National Hospital Registry to identify 3784 (4.3%) children from the cohort diagnosed with 5847 congenital abnormalities.
RESULTS: Children exposed to acetaminophen during the first trimester of pregnancy (n = 26,424) did not have an increased prevalence of congenital abnormalities (hazard ratio = 1.01, 0.93-1.08) compared with nonexposed children (n = 61,718). No association was found between congenital abnormalities and duration of use during the first trimester. Increased prevalence was not observed for specific abnormalities, except for "medial cysts, fistula, sinus" (congenital abnormalities of the ear, face, and neck, ICD-10 code Q18.8, n = 43) with an adjusted hazard ratio of 2.15 (1.17-3.95).
CONCLUSION: Acetaminophen is not associated with an increased prevalence of congenital abnormalities overall or with any specific group of major abnormalities.

• 出版日期2008-2
• 单位河北医科大学