A novel label-free electrochemical immunosensor based on the composite of LPCs-SnS2 and AuNPs for the detection of human chorionic gonadotropin

作者：Wang, Hejie; Guo, Wenjuan^*; Pei, Meishan

来源：New Journal of Chemistry, 2017, 41(20): 11600-11606.

DOI：10.1039/c7nj01774j

• HIERARCHICAL POROUS CARBON
• LITHIUM-ION BATTERIES
• AU NANOPARTICLES
• OPTICAL-PROPERTIES
• SNS2
• GRAPHENE
• ANODE
• NANOCOMPOSITE
• IMMUNOASSAY
• PERFORMANCE

In this study, a novel label-free electrochemical immunosensor was constructed with new layered SnS2 functionalized lignin-based porous carbons (LPCs-SnS2) and gold nanoparticles (AuNPs) as substrates for the sensitive and fast detection of human chorionic gonadotropin (hCG). Vertical SnS2 nanosheet arrays were orderly loaded on LPCs via a facile hydrothermal route, which resulted in a 3D conduction architecture and a large surface area. Based on the high performance of the AuNPs/LPCs-SnS2 composite, an hCG electrochemical immunosensor was successfully fabricated with a wide linear response in the range of 0.5-50 ng mL(-1) and a limit of detection of 6.4 pg mL(-1). The proposed immunosensor displayed good specificity, reproducibility and stability. And finally, it was successfully used for the detection of hCG in a real human serum sample.

• 出版日期2017-10-21
• 单位济南大学