Association between co-inhibitory molecule gene tagging single nucleotide polymorphisms and the risk of colorectal cancer in Chinese

作者：Ge Jie; Zhu Lin; Zhou Junde; Li Guangxiao; Li Ye; Li Shuying; Wu Zhiwei; Rong Jiesheng; Yuan Huiping; Liu Yanhong; Chi Qiang; Piao Daxun; Zhao Yashuang^*; Cui Binbin

来源：Journal of Cancer Research and Clinical Oncology, 2015, 141(9): 1533-1544.

DOI：10.1007/s00432-015-1915-4

• Cytotoxic T lymphocyte antigen-4 (CTLA-4)
• Programmed death 1 (PD-1)
• B and T lymphocyte attenuator (BTLA)
• Single nucleotide polymorphisms (SNPs)
• Colorectal cancer (CRC)

T lymphocyte immune responses are controlled by both co-stimulatory and co-inhibitory signaling through T cell co-receptors. Cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed death 1 (PD-1) and B and T lymphocyte attenuator (BTLA) are all co-inhibitory molecules that negatively regulate the activation of T cells. In this study, we investigated the relationship between ten tagging SNPs in three co-inhibitory molecule genes and colorectal cancer (CRC).
We conducted a hospital-based case-control study consisting of 601 cases with CRC and 627 CRC-free individuals from the Heilongjiang Province of China.
The rs7421861 CT genotype was significantly associated with the risk of colorectal cancer compared to the wild-type TT genotype (adjusted OR 1.314, 95 % CI 1.012-1.706, P = 0.041). The rs2705535 TT genotype was associated with the risk of rectal cancer [OR 1.819 (1.093-3.027), P = 0.021]. There was statistical interaction between the PD-1/rs2227982 (CT + TT) genotypes and high seafood intake (> once/week), as well as the CTLA-4/rs231777 variant and high pungent food intake (> 3 times/week). The AG + AA genotypes of CTLA-4/rs3087243 statistically and antagonistically interacted with soybeans, pork and alcohol intake and were associated with CRC risk. Analogously, BTLA/rs1844089 interacted with pork intake, PD-1/rs7421861 with beef and lamb consumption and PD-1/rs6710479 with barbecue consumption. Haplotype G-C-G-A-T-T-A was significantly associated with CRC risk (OR 1.221 P = 0.034).
These data indicate potential associations between BTLA and PD-1 polymorphisms and CRC susceptibility. Additionally, the three co-inhibitory molecule gene SNPs have environmental interactions associated with CRC risk.

• 出版日期2015-9
• 单位哈尔滨医科大学