An azole-resistant isolate of Malassezia pachydermatis

作者：Nijima Misako; Kano Rui^*; Nagata Masahiko; Hasegawa Atsuhiko; Kamata Hiroshi

来源：Veterinary Microbiology, 2011, 149(1-2): 288-290.

DOI：10.1016/j.vetmic.2010.10.010

• Azole
• Drug susceptibility
• E-test
• Malassezia pachydermatis

Canine Malassezia dermatitis (MD) is frequently treated with systemic ketoconazole (KTZ) and itaconazole (ITZ). However, the antifungal susceptibility of clinical isolates of M. pachydermatis from dogs and cats to the azoles has not been well investigated. In the present study, the in vitro susceptibility of the standard strain (CBS1879: the neotype strain of M. pachydermatis) and 29 clinical isolates of M. pachydermatis to the azoles was measured by a modified CBI M27-A2 test using modified Dixon medium as well as by the E-test. The minimum inhibitory concentrations (MICs) of the 30 isolates of M. pachydermatis (including the neotype strain) against KTZ and ITZ were < 0.03 mu g/ml by the two methods. The MICs of 1 clinical isolate (ASC-11) were 1 and 2 mu g/ml against KTZ, and 2 and 8 mu g/ml against ITZ, by the modified CLSI M27-A2 test and the E-test, respectively. Thus, isolate ASC-11 may be resistant to these azoles, making this the first report of a resistant isolate of M. pachydermatis to KTZ and ITZ.

• 出版日期2011-4-21
• 单位河北医科大学