Urine Tuberculosis Lipoarabinomannan Predicts Mortality in Hospitalized Human Immunodeficiency Virus-Infected Children

作者：LaCourse Sylvia M; Cranmer Lisa M; Njuguna Irene N; Gatimu John; Stern Joshua; Maleche Obimbo Elizabeth; Walson Judd L; Wamalwa Dalton; John Stewart Grace C; Pavlinac Patricia B

来源：Clinical Infectious Diseases, 2018, 66(11): 1798-1801.

DOI：10.1093/cid/ciy011

• children
• mortality
• tuberculosis
• human immunodeficiency virus (HIV)
• lipoarabinomannan
• urine

Despite diagnostic performance limitations, urine lipoarabinomannan (LAM) predicts death in human immunodeficiency virus (HIV)-infected adults with tuberculosis. Pediatric data are limited. Among 137 hospitalized HIV-infected children, mortality was 4.9-fold higher among those with positive LAM (127 vs 31 per 100 person-years; adjusted hazard ratio, 4.92; 95% confidence interval [CI], 1.79-13.49; P = .002). Lipoarabinomannan identifies HIV-infected children at risk for death potentially missed by respiratory sampling.

• 出版日期2018-6-1