Agreement in Cone Density Derived from Gaze-Directed Single Images Versus Wide-Field Montage Using Adaptive Optics Flood Illumination Ophthalmoscopy

作者：Chew, Avenell L.; Sampson, Danuta M.; Kashani, Irwin; Chen, Fred K.^*

来源：Translational Vision Science & Technology, 2017, 6(6): 9.

DOI：10.1167/tvst.6.6.9

• rtx1 adaptive optics camera
• retinal imaging
• preferred retinal locus
• foveal center
• clinical trials endpoint

Purpose: We compared cone density measurements derived from the center of gazedirected single images with reconstructed wide-field montages using the rtx1 adaptive optics (AO) retinal camera.
Methods: A total of 29 eyes from 29 healthy subjects were imaged with the rtx1 camera. Of 20 overlapping AO images acquired, 12 (at 3.2 degrees, 5 degrees, and 7 degrees) were used for calculating gaze-directed cone densities. Wide-field AO montages were reconstructed and cone densities were measured at the corresponding 12 loci as determined by field projection relative to the foveal center aligned to the foveal dip on optical coherence tomography. Limits of agreement in cone density measurement between single AO images and wide-field AO montages were calculated.
Results: Cone density measurements failed in 1 or more gaze directions or retinal loci in up to 58% and 33% of the subjects using single AO images or wide-field AO montage, respectively. Although there were no significant overall differences between cone densities derived from single AO images and wide-field AO montages at any of the 12 gazes and locations (P - 0.01-0.65), the limits of agreement between the two methods ranged from as narrow as 2200 to vertical bar 2600, to as wide as 4200 to vertical bar 3800 cones/mm(2).
Conclusions: Cone density measurement using the rtx1 AO camera is feasible using both methods. Local variation in image quality and altered visibility of cones after generating montages may contribute to the discrepancies.

• 出版日期2017-11