N,N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA): Peroxisome proliferator-activated receptor (PPAR-gamma) agonists with neuroprotective properties

作者：Madonna Sebastien; Maher Pamela^*; Kraus Jean Louis

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(23): 6966-6968.

DOI：10.1016/j.bmcl.2010.09.134

• Neuroprotection
• N,N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines
• PPAR-gamma agonists

We report on the neuroprotective effects of N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA) in a model of oxidative stress-induced nerve cell death using mouse hippocampal-derived HT22 cells. The four derivatives (JLK1472, JLK1486, JLK1522 and JLK1535) protected the HT22 cells from death at concentrations ranging from 0.1 to 1 mu M. Their action is partially dependent on their ability to act as PPAR gamma agonists. These analogues also maintain GSH levels suggesting that they have indirect anti-oxidant effects.

• 出版日期2010-12-1