Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA syndrome) in commercial sheep

作者：Lujan Lluis^*; Perez Marta; Salazar Eider; Alvarez Neila; Gimeno Marina; Pinczowski Pedro; Irusta Silvia; Santamaria Jesus; Insausti Nerea; Cortes Yerzol; Figueras Luis; Cuartielles Isabel; Vila Miguel; Fantova Enrique; Gracia Chapulle Jose Luis

来源：Immunologic Research, 2013, 56(2-3): 317-324.

DOI：10.1007/s12026-013-8404-0

• Sheep
• Aluminum
• Vaccines
• Adjuvant
• Autoimmunity
• Cachexia
• Intoxication

We describe a form of the autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA syndrome) in commercial sheep, linked to the repetitive inoculation of aluminum-containing adjuvants through vaccination. The syndrome shows an acute phase that affects less than 0.5 % of animals in a given herd, it appears 2-6 days after an adjuvant-containing inoculation and it is characterized by an acute neurological episode with low response to external stimuli and acute meningoencephalitis, most animals apparently recovering afterward. The chronic phase is seen in a higher proportion of flocks, it can follow the acute phase, and it is triggered by external stimuli, mostly low temperatures. The chronic phase begins with an excitatory phase, followed by weakness, extreme cachexia, tetraplegia and death. Gross lesions are related to a cachectic process with muscular atrophy, and microscopic lesions are mostly linked to a neurodegenerative process in both dorsal and ventral column of the gray matter of the spinal cord. Experimental reproduction of ovine ASIA in a small group of repeatedly vaccinated animals was successful. Detection of Al(III) in tissues indicated the presence of aluminum in the nervous tissue of experimental animals. The present report is the first description of a new sheep syndrome (ovine ASIA syndrome) linked to multiple, repetitive vaccination and that can have devastating consequences as it happened after the compulsory vaccination against bluetongue in 2008. The ovine ASIA syndrome can be used as a model of other similar diseases affecting both human and animals. A major research effort is needed in order to understand its complex pathogenesis.

• 出版日期2013-7