Amelioration of streptozotocin-induced diabetes by Agrocybe chaxingu polysaccharide

作者：Lee Byung Ryong; Lee Yeom Pyo; Kim Dae Won; Song Ha Yong; Yoo Ki Yeon; Won Moo Ho; Kang Tae Cheon; Lee Kwang Jae; Kim Kyung Hee; Joo Jin Ho; Ham Hun Ju; Hur Jang Hyun; Cho Sung Woo; Han Kyu Hyung; Lee Kil Soo; Park Jinseu; Eum Won Sik^*; Choi Soo Young

来源：Molecules and Cells, 2010, 29(4): 349-354.

DOI：10.1007/s10059-010-0044-9

• Agrocybe chaxingu
• blood glucose
• nitric oxide (NO)
• polysaccharide

The aim of this study was to investigate the preventive effect of Agrocybe chaxingu polysaccharide on streptozocin (STZ)-induced pancreatic beta-cells destruction. Agrocybe chaxingu polysaccharide markedly reduced nitric oxide (NO) production and iNOS expression levels in RINm5F cells in a dose-dependent manner. In addition, Agrocybe chaxingu polysaccharide significantly inhibited iNOS expression and blood glucose levels in STZ-induced diabetic mice. Moreover, immunohistochemical analysis revealed that it enhanced pancreatic beta-cells resistance to destruction by STZ. These results suggest that Agrocybe chaxingu polysaccharide may have value as a therapeutic agent against diabetes mellitus.

• 出版日期2010-4