Dronedarone for Atrial Fibrillation Have We Expanded the Antiarrhythmic Armamentarium?

作者：Singh David; Cingolani Eugenio; Diamond George A; Kaul Sanjay^*

来源：Journal of the American College of Cardiology, 2010, 55(15): 1569-1576.

DOI：10.1016/j.jacc.2009.10.071

• atrial fibrillation
• atrial flutter
• antiarrhythmic agents
• heart failure

Dronedarone is a new antiarrhythmic agent that was recently approved for the prevention of cardiovascular hospitalization driven by atrial fibrillation/flutter. Its approval was based largely on the results of the ATHENA (A Placebo-Controlled, Double-Blind, Parallel Arm Trial to Assess the Efficacy of Dronedarone 400 mg bid for the Prevention of Cardiovascular Hospitalization or Death From Any Cause in Patients With Atrial Fibrillation/Atrial Flutter) trial, which demonstrated a significant 24% reduction in the combined end point of all-cause mortality and cardiovascular hospitalization, primarily driven by the latter. However, several other clinical trials have evaluated the impact of dronedarone on various cardiovascular end points and yielded mixed results. In this article, we summarize the available evidence concerning dronedarone, and offer practical recommendations to health care providers regarding its use in the treatment of atrial fibrillation. We conclude that the available data support the use of dronedarone in select patient populations as a second- or third-line agent.

• 出版日期2010-4-13