Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease

作者：Kiani Anita^*; Brun Vanessa; Laine Fabrice; Turlin Bruno; Morcet Jeff; Michalak Sophie; Le Gruyer Antonia; Legros Ludivine; Bardou Jacquet Edouard; Gandon Yves; Moirand Romain

来源：World Journal of Gastroenterology, 2016, 22(20): 4926-4935.

DOI：10.3748/wjg.v22.i20.4926

• Alcoholic liver disease
• Elastography
• Non-invasive
• Acoustic radiation force impulse
• Fibrosis

AIM: To evaluate the performance of elastography by ultrasound with acoustic radiation force impulse (ARFI) in determining fibrosis stage in patients with alcoholic liver disease (ALD) undergoing alcoholic detoxification in relation to biopsy.
METHODS: Eighty-three patients with ALD undergoing detoxification were prospectively enrolled. Each patient underwent ARFI imaging and a liver biopsy on the same day. Fibrosis was staged according to the METAVIR scoring system. The median of 10 valid ARFI measurements was calculated for each patient.
RESULTS: Sixty-nine males and thirteen females (one patient excluded due to insufficient biopsy size) were assessed with a mean alcohol consumption of 132.4 +/- 128.8 standard drinks per week and mean cumulative year duration of 17.6 +/- 9.5 years. Sensitivity and specificity were respectively 82.4% (0.70-0.95) and 83.3% (0.73-0.94) (AUROC = 0.87) for F >= 2 with a cut-off value of 1.63m/s; 82.4% (0.64-1.00) and 78.5% (0.69-0.89) (AUROC = 0.86) for F >= 3 with a cut-off value of 1.84m/s; and 92.3% (0.78-1.00] and 81.6% (0.72-0.90) (AUROC = 0.89) for F = 4 with a cut-off value of 1.94 m/s.
CONCLUSION: ARFI is an accurate, non-invasive and easy method for assessing liver fibrosis in patients with ALD undergoing alcoholic detoxification.

• 出版日期2016-5-28