Decreased HIV Type 1 Transcription in CCR5-Delta 32 Heterozygotes During Suppressive Antiretroviral Therapy

作者：Wang Charlene; Abdel Mohsen Mohamed; Strain Matthew C; Lada Steven M; Yukl Steven; Cockerham Leslie R; Pilcher Christopher D; Hecht Frederick M; Sinclair Elizabeth; Liegler Teri; Richman Douglas D; Deeks Steven G; Pillai Satish K^*

来源：Journal of Infectious Diseases, 2014, 210(11): 1838-1843.

DOI：10.1093/infdis/jiu338

• HIV
• CCR5
• Delta 32
• coreceptor
• reservoir
• latency
• eradication
• NF-kappa B
• HIV transcription
• HIV replication

Individuals who are heterozygous for the CCR5-Delta 32 mutation provide a natural model to examine the effects of reduced CCR5 expression on human immunodeficiency virus (HIV) persistence. We evaluated the HIV reservoir in 18 CCR5-Delta 32 heterozygotes and 54 CCR5 wild-type individuals during suppressive antiretroviral therapy. Cell-associated HIV RNA levels (P = .035), RNA to DNA transcriptional ratios (P = .013), and frequency of detectable HIV 2-long terminal repeat circular DNA (P = .013) were significantly lower in CD4(+) T cells from CCR5-Delta 32 heterozygotes. Cell-associated HIV RNA was significantly correlated with CCR5 surface expression on CD4(+) T cells (r(2) = 0.136; P = .002). Our findings suggest that curative strategies should further explore manipulation of CCR5.

• 出版日期2014-12-1