How to improve the immunogenicity of chemotherapy and radiotherapy

作者：Ma Yuting; Conforti Rosa; Aymeric Laetitia; Locher Clara; Kepp Oliver; Kroemer Guido; Zitvogel Laurence^*

来源：Cancer and Metastasis Reviews, 2011, 30(1): 71-82.

DOI：10.1007/s10555-011-9283-2

• Cell death
• DAMP
• Tumor microenvironment
• Immune cells

Chemotherapy or radiotherapy could induce various tumor cell death modalities, releasing tumor-derived antigen as well as danger signals that could either be captured for triggering antitumor immune response or ignored. Exploring the interplay among therapeutic drugs, tumor cell death and the immune cells should improve diagnostic, prognostic, predictive, and therapeutic management of tumor. We summarized some of the cell death-derived danger signals and the mechanism for host to sense and response to cell death in the tumor microenvironment. Based on the recent clinical or experimental findings, several strategies have been suggested to improve the immunogenicity of cell death and augment antitumor immunity.

• 出版日期2011-3