Altered immunodominance hierarchies of CD8+T cells in the spleen after infection at different sites is contingent on high virus inoculum

作者：Siddiqui Sarah; Tarrab Esther; Lamarre Alain; Basta Sameh^*

来源：Microbes and Infection, 2010, 12(4): 324-330.

DOI：10.1016/j.micinf.2010.01.004

• MHC
• Antigen presentation/processing
• Peptides/epitopes and viral antigens

Activated epitope-specific CD8+ T cells after virus infection can be organized into hierarchies (immunodominance), based on their ability to focus the response on few viral determinants The mechanisms responsible for immunodominance can be multifactorial, with CD8+ T cells precursor frequencies recently highlighted as a key regulator Employing the LCMV infection model, we demonstrate that the hierarchies were altered when comparing different sites of infection but only at high viral doses These findings have significant i

• 出版日期2010-4