A highly selective and sensitive fluorescent chemosensor for distinguishing cadmium(II) from zinc(II) based on amide tautomerization

作者：Zhang, Yuanyuan; Chen, Xiangzhu; Liu, Jingjing; Gao, Gui; Zhang, Xueyan; Hou, Shicong^*; Wang, Hongmei^*

来源：New Journal of Chemistry, 2018, 42(23): 19245-19251.

DOI：10.1039/c8nj03465f

• DISTINGUISHING CD2+
• MOLECULAR SWITCH
• AQUEOUS-SOLUTION
• SENSOR
• PROBE
• ZN2+
• IONS
• WATER
• COMPLEX
• CYCLODEXTRIN

A naphthalimide-derived fluorescent sensor termed L2 was designed and synthesized. This sensor showed a highly selective, sensitive, and reversible turn-on response to Cd2+ over other metal ions in a wide pH range with a detection limit of 2.35 x 10(-10) M. The amide/di-2-picolylamine receptor binds Cd2+ in the imidic acid tautomeric form but other metal ions in the amide tautomeric form. Moreover, the sensor can be used to distinguish Cd2+ and Zn2+ with the naked eye. The Cd2+-binding mode and the recognition mechanism of the sensor were investigated using Job's plot, H-1 NMR, HRMS, IR and DFT calculations. Furthermore, the sensor was successfully applied as the active component of indicator papers for on-site detection of Cd2+ in pure water and in fluorescence imaging of Cd2+ in HeLa cells.

• 出版日期2018-12-7
• 单位中国农业大学