Acyl Azolium Fluorides for Room Temperature Nucleophilic Aromatic Fluorination of Chloro- and Nitroarenes

作者：Ryan Sarah J; Schimler Sydonie D; Bland Douglas C; Sanford Melanie S^*

来源：Organic Letters, 2015, 17(8): 1866-1869.

DOI：10.1021/acs.orglett.5b00538

The reaction of acid fluorides with N-heterocyclic carbenes (NHCs) produces anhydrous acyl azolium fluorides. With appropriate selection of acid fluoride and NHC, these salts can be used for the room temperature SNAr fluorination of a variety of aryl chlorides and nitroarenes.

• 出版日期2015-4-17