Molecular therapy for bone regeneration in horses

作者：Bertone Alicia L^*; Ishihara Akikazu

来源：Pferdeheilkunde, 2010, 26(4): 625-628.

• gene therapy
• fracture healing
• osteoinduction
• local drug delivery
• delivery vectors

Complicated and catastrophic fractures in horses have high failure rates. Horses often succumb to bone nonunion or contralateral limb third phalanx rotation as a consequence of long-term lameness of the fractured limb. Molecular therapy has proven useful for the acceleration of bone repair and regeneration. Even a transient local production of osteoinductive growth factor may induce a clinically relevant degree of bone formation. Molecular, or gene, therapy locally delivers a nucleotide sequence that encodes for an effective growth factor to the site of fracture healing to increase the local concentration of this growth factor. Direct gene therapy has shown to be effective for in vitro bone formation and in vivo healing acceleration by using various viral and nonviral gene delivery vectors. Cell-mediated gene therapy has also been successfully performed by using wide range of carrier cells. These cell-mediated and direct gene therapies have provided numerous promising results in recent years and may become as practical alternative solutions for the potential treatments of equine bone repair and regeneration.

• 出版日期2010-8