Anergic T Cells Are Metabolically Anergic

作者：Zheng Yan; Delgoffe Greg M; Meyer Christian F; Chan Waipan; Powell Jonathan D^*

来源：The Journal of Immunology, 2009, 183(10): 6095-6101.

DOI：10.4049/jimmunol.0803510

Full T cell activation requires TCR engagement (signal 1) in the context of costimulation (signal 2). Costimulation is required for maximal expression of effector cytokines and prevention of T cell anergy. It has become increasingly clear that another major function of costimulation is to up-regulate the metabolic machinery necessary for T cell function. In this report we demonstrate that anergic T cells are metabolically anergic, in that upon full stimulation (signals 1 plus 2) they fail to up-regulate the machinery necessary to support increased metabolism. These findings suggest that one mechanism responsible for the maintenance of T cell anergy is failure to up-regulate the metabolic machinery. Furthermore, we demonstrate that by blocking leucine, glucose, and energy metabolism, T cell activation is mitigated. Additionally, inhibition of these metabolic pathways during T cell activation leads to anergy in Th1-differentiated cells. Overall, our findings extend the role of T cell metabolism in regulating T cell function. The Journal of Immunology, 2009, 183: 6095-6101.

• 出版日期2009-11-15