Derivatives of Photosensitive CORM-S1-CO Complexes of Iron and Ruthenium with the (OC)(2)M(S-C-C-NH2)(2) Fragment

作者：Velasquez Vaneza P Lorett; Jazzazi Taghreed M A; Malassa Astrid; Goerls Helmar; Gessner Guido; Heinemann Stefan H; Westerhausen Matthias^*

来源：European Journal of Inorganic Chemistry, 2012, (7): 1072-1078.

DOI：10.1002/ejic.201101230

• Carbonyl ligands
• Carbon monoxide
• CO-releasing molecules
• Iron
• Ruthenium
• Medicinal chemistry

[Fe(CO)(2)(SCH2CH2NH2)(2)] (1, CORM-S1), [Fe(CO)(2)(SC6H4-2- NH2)(2)] (2, CORM-S2), [Ru(CO)(2)(SCH2CH2NH2)(2)] (3), and [Ru(CO)(2)(SC6H4-2-NH2)(2)] (4) were prepared from the corresponding metal carbonyl compounds and cysteamine (deprotonation of the thiol functionality) or cystamine (oxidative addition of the S-S bond). They crystallized from donor sol-vents, such as tetrahydrofuran and dimethylformamide, as adducts with the bases bound by hydrogen bridges to the amino functionalities. Although the iron derivatives proved to be valuable photosensitive CO-releasing molecules (CORMs), CO was not released from the ruthenium analogs with visible light.

• 出版日期2012-3