Differences in ovarian hormones in relation to parity and time since last birth

作者：Barrett Emily S^*; Parlett Lauren E; Windham Gayle C; Swan Shanna H

来源：Fertility and Sterility, 2014, 101(6): 1773-U361.

DOI：10.1016/j.fertnstert.2014.02.047

• Estradiol
• fecundity
• motherhood
• menstrual cycle
• ovarian function

Objective: To examine ovarian function in relation to parity and time since last birth. %26lt;br%26gt;Design: Cross-sectional study. %26lt;br%26gt;Setting: Health-care program in California. %26lt;br%26gt;Patient(s): 346 naturally cycling women, aged 18 to 39 years. %26lt;br%26gt;Intervention(s): None. %26lt;br%26gt;Main Outcome Measure(s): Mean follicular urinary estradiol metabolite concentration (E1C) (cycle days -8 to -1), mean luteal progesterone metabolite concentration (PdG) (days 0 to +10), and cycle phase lengths in ovulatory cycles. %26lt;br%26gt;Result(s): After the women had collected daily urine samples for up to eight menstrual cycles, we measured the E1C and PdG using enzyme-linked immunoassay. The cycle phase lengths were calculated from the hormone profiles and daily diaries. Women who had given birth within the previous 3 years had lower E1C than the nulliparous women and women who last given birth %26gt;3 years earlier. Among the parous women, E1C was positively associated with the time since last birth. Women who last gave birth %26gt;3 years earlier had longer follicular phases than the nulliparous women. There were no associations between parity and PdG or luteal phase length. %26lt;br%26gt;Conclusion(s): Our cross-sectional data suggest that ovarian function differs in nulliparous and parous women and is positively associated with the time since last birth. Longitudinal research is needed to explore within-woman changes in ovarian function prepartum and postpartum.

• 出版日期2014-6