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摘要
Objectives: Type2 diabetes (T2DM) is the most common subtype of diabetes mellitus. A number of studies have examined the role of genetic polymorphisms on the risk of T2DM, and several variants have been identified as potential susceptibility genes, of those angiotensin-converting enzyme (ACE I/D) and angiotensinogen (AGT M235T). The aim of the current study was to investigate the association between genetic polymorphisms of ACE I/D and AGT M235T genes and T2DM in Egyptian population. Design and methods: A case control study was performed on 138 Egyptian subjects, 58 T2DM patients without hypertension with mean disease duration 7.8 +/- 2.1 years and 80 age, and sex matching unrelated healthy controls. Genotyping of the candidate genes were performed by polymerase chain reaction technique (PCR) for ACE I/D gene and by PCR followed by restriction fragment length polymorphism (RFLEP) for AGT M235T gene and the presence or absence of the genotypes was analyzed by gel electrophoresis. We examined the association between each polymorphism and the risk of T2DM by odds ratio (OR) with 95% confidence intervals (95% CI). Results; Individuals who carried the two risk genotypes ACE (DD)/AGT (TT) had 14.5 times (95% CI 1.783-118.083, p = 0.012) higher risk of developing T2DM than those who carry one risk genotype. ACE (DD) genotype OR = 2.444, 95% CI 1.140-5.240, p = 0.022 and AGT (TT) genotype OR = 3.9, 95% CI 1.773-8.597, p %26lt; 0.001. Conclusion: These data indicate an evident association between genetic polymorphisms of ACE I/D and AGT M235T genes and T2DM in Egyptian population. [Soheir Badr, Naglaa Raafat Abd Raboh and Samia Ali. Angiotensinogen M235T and angiotensin-converting enzyme I/D gene polymorphism and their association with type 2 diabetes in Egypt. Life Sci J 2012;9(2):1226-1233]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 183
- 出版日期2012
